US Patent Issued to The General Hospital on Dec. 30 for "Agonistic tumor necrosis factor receptor superfamily polypeptides" (Massachusetts Inventor)

ALEXANDRIA, Va., Dec. 31 -- United States Patent no. 12,509,521, issued on Dec. 30, was assigned to The General Hospital Corp. (Boston).

"Agonistic tumor necrosis factor receptor superfamily polypeptides" was invented by Denise L. Faustman (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described are agonistic TNFR2 polypeptides, such as antibodies and antigen-binding fragments thereof, and the use of these polypeptides to stimulate the proliferation of regulatory T cells (Treg cells) and/or myeloid-derived suppressor cells (MDSCs), as well as to inhibit the function of, reduce the proliferation of, and/or directly kill, T effector cells, such as CD8+ T effector cells. The polypeptides, such as antibo...