US Patent Issued to The Cleveland Clinic Foundation on Oct. 7 for "Generating dorsal foregut, and anterior domain, endoderm cells" (Ohio Inventors)

ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,435,315, issued on Oct. 7, was assigned to The Cleveland Clinic Foundation (Cleveland).

"Generating dorsal foregut, and anterior domain, endoderm cells" was invented by Jan Jensen (Cleveland) and Michael A. Bukys (Cleveland).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are compositions, systems, kits, and methods for generating dorsal foregut endoderm (DFE) cells by contacting pluripotent stem cells with a retinoic acid signaling pathway agonist and a bone morphogenetic (BMP) pathway inhibitor without exposing the stem cells to a transforming growth factor beta (TGFBeta) pathway agonist. In certain embodiments, the DFE cells are contacte...