US Patent Issued to The Cleveland Clinic Foundation, Case Western Reserve University on Dec. 16 for "Detection for determining corticosteroid responsiveness" (Ohio Inventors)

ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,496,305, issued on Dec. 16, was assigned to The Cleveland Clinic Foundation (Cleveland) and Case Western Reserve University (Cleveland).

"Detection for determining corticosteroid responsiveness" was invented by Nima Sharifi (Shaker Heights, Ohio), Joe G. Zein (Mayfield Heights, Ohio) and Benjamin Gaston (Gates Mills, Ohio).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to methods, kits, and compositions for testing a sample from a subject with asthma to determine: i) if the subject is A/A or A/C at position 1245 in the HSD3B1 gene, and/or if the subject expresses a 367N version of the 3Beta-HSD1 protein (e.g., and should be ...