ALEXANDRIA, Va., April 2 -- United States Patent no. 12,264,323, issued on April 1, was assigned to THE BROAD INSTITUTE INC. (Cambridge, Mass.).
"CRISPR CPF1 direct repeat variants" was invented by John G. Doench (Cambridge, Mass.) and Ruth Hanna (Cambridge, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention generally relates to systems, methods and compositions related to Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and components thereof. Provided herein are engineered Cpf1 polynucleotides that can direct the activity of a CRISPR protein to multiple targets using a single crRNA. The guide sequences can target a sequence in a eukaryotic cell, for example, an ani...