US Patent Issued to The Broad Institute, The Brigham and Womens's Hospital on Sept. 23 for "Methods and compositions for optochemical control of CRISPR-CAS9" (Massachusetts Inventors)

ALEXANDRIA, Va., Sept. 23 -- United States Patent no. 12,421,507, issued on Sept. 23, was assigned to The Broad Institute Inc. (Cambridge, Mass.) and The Brigham and Womens's Hospital Inc. (Boston).

"Methods and compositions for optochemical control of CRISPR-CAS9" was invented by Amit Choudhary (Boston), Debasish Manna (Boston), Basudeb Maji (Cambridge, Mass.) and Soumyashree Ashok Gangopadhyay (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "The disclosure includes non-naturally occurring or engineered DNA- or RNA-guided nuclease systems, comprising CRISPR enzymes associated with at least one destabilization domain (DD) and photocaged stabilization ligands with at least one photocage molecule, along ...