US Patent Issued to THE BROAD INSTITUTE, Massachusetts Institute of Technology, PRESIDENT AND FELLOWS OF HARVARD COLLEGE on Sept. 23 for "Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation" (Massachusetts Inventors)

ALEXANDRIA, Va., Sept. 23 -- United States Patent no. 12,421,506, issued on Sept. 23, was assigned to THE BROAD INSTITUTE INC. (Cambridge, Mass.), Massachusetts Institute of Technology (Cambridge, Mass.) and PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Mass.).

"Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation" was invented by Fei Ran (Cambridge, Mass.) and Feng Zhang (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Ca...