ALEXANDRIA, Va., June 25 -- United States Patent no. 12,338,250, issued on June 24, was assigned to The Broad Institute Inc. (Cambridge, Mass.) and Bayer AG (Leverkusen, Germany).

"Methods of preparing macrocyclic indoles" was invented by Kai Thede (Leverkusen, Germany), Sven Wittrock (Leverkusen, Germany), Anne Mengel (Leverkusen, Germany), David McKinney (Cambridge, Mass.), Christopher Lemke (Cambridge, Mass.), Steven J. Ferrara (Cambridge, Mass.), Laura Furst (Cambridge, Mass.), Guo Wei (Cambridge, Mass.) and Patrick R. McCarren (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to methods of preparing substituted indole derivatives of general formula (I):in whi...