US Patent Issued to TeneoBio on Dec. 16 for "Transgenic non-human animals producing modified heavy chain-only antibodies" (California Inventors)

ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,495,776, issued on Dec. 16, was assigned to TeneoBio Inc. (Thousand Oaks, Calif.).

"Transgenic non-human animals producing modified heavy chain-only antibodies" was invented by Wim van Schooten (Sunnyvale, Calif.), Nathan Trinklein (Redwood City, Calif.), Shelley Force Aldred (Hayward, Calif.), Marianne Bruggemann (Menlo Park, Calif.) and Mike Osborn (Menlo Park, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Human or chimeric heavy chain-only antibodies are provided, in the native amino acid residue at the first position of the fourth framework region (FR4) of said HCAb is substituted by a different amino acid residue that is capable of disrupti...