ALEXANDRIA, Va., June 4 -- United States Patent no. 12,319,940, issued on June 3, was assigned to Takeda Pharmaceutical Co. Ltd. (Osaka Shi, Japan).

"Methods for purification of arylsulfatase A" was invented by Dave Nichols (Lexington, Mass.), Igor Quinones-Garcia (Lexington, Mass.), Bee Lin Cheang (Lexington, Mass.) and Mei Huei Jang (Lexington, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides, among other things, improved methods for purifying arylsulfatase A (ASA) protein produced recombinantly for enzyme replacement therapy. The present invention is, in part, based on the surprising discovery that recombinant ASA protein can be purified from unprocessed biological mater...