ALEXANDRIA, Va., Sept. 23 -- United States Patent no. 12,421,526, issued on Sept. 23, was assigned to TAKARA BIO INC. (Shiga, Japan).
"AAV mutant having brain-targeting property" was invented by Toshikazu Nishie (Kusatsu, Japan), Fuyuko Takashima (Kusatsu, Japan), Tatsuji Enoki (Kusatsu, Japan), Junichi Mineno (Kusatsu, Japan) and Yoshinori Tanaka (Kusatsu, Japan).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a nucleic acid which encodes an adeno-associated virus (AAV) capsid protein mutant that contains a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID Nos. 15 to 62 or a peptide comprising an amino acid sequence produced by substituting, ...