US Patent Issued to SYSMEX on April 8 for "Method for improving affinity of antibody for antigen and use thereof" (Japanese Inventors)

ALEXANDRIA, Va., April 9 -- United States Patent no. 12,269,895, issued on April 8, was assigned to SYSMEX Corp. (Kobe, Japan).

"Method for improving affinity of antibody for antigen and use thereof" was invented by Tomofumi Nakada (Kobe, Japan), Yuriko Egashira (Kobe, Japan) and Atsushi Fukunaga (Kobe, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed is a method for improving affinity of an antibody for an antigen, the method comprising: in the antibody, changing at least 3 amino acid residues of framework region 3 (FR3) as defined by Kabat method to arginine residues or lysine residues, thereby improving affinity of an antibody for an antigen as compared with that of an antibody before said a...