US Patent Issued to Synthon on Jan. 13 for "Process for preparation of Axitinib" (Czech Inventors)

ALEXANDRIA, Va., Jan. 13 -- United States Patent no. 12,522,581, issued on Jan. 13, was assigned to Synthon B.V. (Nijmegen, Netherlands).

"Process for preparation of Axitinib" was invented by Jakub Castulik (Blansko, Czech Republic) and Radomir Skoumal (Blansko, Czech Republic).

According to the abstract* released by the U.S. Patent & Trademark Office: "In a process of making Axitinib, a palladium catalyst is added to a mixture of 2-vinylpyridine and the protected intermediate of formula (III) to form protected-Axitinib of formula (IV).In the formulas, P is a protective group and X is I, Cl, Br, or trifluoromethanesulfonate. The palladium catalyst is prepared separately, before being added to the reaction mixture, and is made from a mixtu...