ALEXANDRIA, Va., Oct. 21 -- United States Patent no. 12,440,540, issued on Oct. 14, was assigned to Synthekine Inc. (Menlo Park, Calif.).
"IL-2 orthologs and methods of use" was invented by Paul-Joseph Penaflor-Aspuria (Redwood City, Calif.), Scott Alan McCauley (Menlo Park, Calif.), Martin Oft (Palo Alto, Calif.) and Steve Kauder (Menlo Park, Calif.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to hIL2 orthogonal ligands ("IL2 orthologs") that specifically and selectively bind to the extracellular domain (ECD) a transmembrane polypeptide comprising of a modified hCD122 polypeptide. The binding of the hIL2 ortholog to the modified hCD122 polypeptide participates in the transdu...