ALEXANDRIA, Va., Sept. 10 -- United States Patent no. 12,410,393, issued on Sept. 9, was assigned to Sutro Biopharma Inc. (South San Francisco, Calif.).
"E. coli strains having an oxidative cytoplasm" was invented by Daniel Groff (Alameda, Calif.).
According to the abstract* released by the U.S. Patent & Trademark Office: "This disclosure provides an E. coli strain, which lacks thioredoxin reductase activity encoded by trxB and thioredoxin 1 activity encoded by trxA, and glutathione reductase activity encoded by gor. Said E. coli strain expresses a mutated AhpC protein having glutathione reductase activity and a cytosolic prokaryotic disulfide isomerase. The E. coli strain has an oxidative cytosol and can be used to efficiently produce pr...