US Patent Issued to Sutro Biopharma on July 8 for "Methods of producing full-length antibodies using E. coli" (California Inventors)

ALEXANDRIA, Va., July 9 -- United States Patent no. 12,351,850, issued on July 8, was assigned to Sutro Biopharma Inc. (South San Francisco, Calif.).

"Methods of producing full-length antibodies using E. coli" was invented by Daniel Groff (Alameda, Calif.) and Jeffrey Hanson (Oakland, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "This disclosure provides a method of producing full-length antibodies in E. coli with a yield of at least about 200 mg/L. The E. coli cells typically have an oxidative cytoplasm, which is helpful for maintaining the three-dimensional structure and stability of proteins having disulfide bonds. In some cases, the molar ratio of the produced HC and LC amount from culturing the ...