ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,454,535, issued on Oct. 28, was assigned to Supernus Pharmaceuticals Inc. (Rockville, Md.).

"Substituted derivatives of isoindoles" was invented by Gary L. Olson (Mountainside, N.J.), Bhaskara Rao Nallaganchu (Hillsborough, N.J.) and Yanjun Sun (Kendall Park, N.J.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are substituted derivatives of 5-(4-chlorophenyl)-2,3-dihydroimidazo[1,2-b]isoindol-5-ol having Formula (I):as well as their stereoisomers and their pharmaceutically acceptable salts. Such substituted derivatives may be used, for example, in pharmaceutical compositions for the treatment of central nervous system diseases or disorders. In ...