US Patent Issued to SunVax mRNA Therapeutics on Sept. 16 for "Synthetic self-amplifying MRNA molecules with secretion antigen and immunomodulator" (Massachusetts Inventors)

ALEXANDRIA, Va., Sept. 17 -- United States Patent no. 12,416,032, issued on Sept. 16, was assigned to SunVax mRNA Therapeutics Inc. (Beverly, Mass.).

"Synthetic self-amplifying MRNA molecules with secretion antigen and immunomodulator" was invented by Yingzhong Li (Reading, Mass.) and Libin Zhang (Lynnfield, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Lipid nanoparticle (LNP) encapsulating self-amplifying mRNA, compositions, and methods of using the novel nucleic acid constructs and compositions are disclosed. LNP constructs include novel ionizable lipid. Novel sa-mRNA constructs encode a modified SARS-COV-2 spike protein, wherein the polynucleotide has been truncated to not include nucleotides enco...