US Patent Issued to ST. JUDE CHILDREN'S RESEARCH HOSPITAL on May 13 for "Cloning and expression system for T-cell receptors" (Tennessee Inventors)

ALEXANDRIA, Va., June 12 -- United States Patent no. 12,297,427, issued on May 13, was assigned to ST. JUDE CHILDREN'S RESEARCH HOSPITAL INC. (Memphis, Tenn.).

"Cloning and expression system for T-cell receptors" was invented by Paul Thomas (Memphis, Tenn.), Xizhi Guo (Memphis, Tenn.) and Pradyot Dash (Memphis, Tenn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides a method for rapid cloning of T-cell receptors (TCRs) (e.g., paired AlphaBeta and GammaDelta TCR chains) and B-cell receptors (BCRs) (e.g. paired IgH or IgK or IgLambda) from single cells by CDR3 substitution using single cell PCR products and Gibson Assembly techniques and a pre-generated TCR (or BCR) library in an expression...