US Patent Issued to SONNET BIOTHERAPEUTICS on April 29 for "Interleukin 18 (IL-18) variants and fusion proteins comprising same" (New Jersey, New Hampshire Inventors)

ALEXANDRIA, Va., June 9 -- United States Patent no. 12,286,463, issued on April 29, was assigned to SONNET BIOTHERAPEUTICS INC. (Princeton, N.J.).

"Interleukin 18 (IL-18) variants and fusion proteins comprising same" was invented by John K. Cini (Blairstown, N.J.) and Susan J. Dexter (Rye, N.H.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are variant human IL-18 (hIL-18) proteins and fusion proteins comprising the variant hIL-18 proteins. Such variant hIL-18 proteins exhibit biological IL-18 activity while having reduced or no detectable binding to inhibitory IL-18BP. Thus, in some embodiments, the variant hIL-18 proteins advantageously retain IL-18 biological activity in the presence of IL...