ALEXANDRIA, Va., Nov. 18 -- United States Patent no. 12,472,259, issued on Nov. 18, was assigned to SMARTDYELIVERY GMBH (Jena, Germany).

"PKC inhibitors for the treatment of septic cholestasis with polymethine dye targeting" was invented by Christoph Enzensperger (Jena, Germany) and Marc Lehmann (Jena, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to inhibitors of the PKC signaling pathway for use in the treatment of septic cholestasis, wherein the inhibitors are targeted into the liver by a selective nanostructured delivery system, wherein the selective nanostructured delivery system comprises at least one polymethine dye and at least one polymer and/or at least one lipid and/...