ALEXANDRIA, Va., July 9 -- United States Patent no. 12,350,377, issued on July 8, was assigned to Shionogi & Co. Ltd. (Osaka, Japan).

"Preparation containing 6,7-unsaturated-7-carbamoyl morphinan derivatives" was invented by Akira Mashimo (Osaka, Japan), Shunji Ichio (Osaka, Japan), Yoshinori Tamura (Osaka, Japan) and Kouichi Noguchi (Hyogo, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "The solid preparation which improved the dissolution profile and the stability of the 6,7-unsaturation-7-carbamoyl morphinan derivative is provided. When 6,7-unsaturation-7-carbamoyl morphinan derivative, croscarmellose sodium and ferric oxide were contained, not titanium oxide in the solid preparations and the coating...