ALEXANDRIA, Va., June 6 -- United States Patent no. 12,281,094, issued on April 22, was assigned to SHENZHEN ZINWI BIO-TECH Co. LTD (Guangdong, China).
"Preparation method of racemic nicotine" was invented by Jun Zou (Guangdong, China), Yang Zou (Guangdong, China), Meisen Liu (Guangdong, China) and Weixian Luo (Guangdong, China).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present application provides a preparation method of racemic nicotine, including the following steps: Nicotinyl chloride and methylamine are reacted under alkaline conditions to obtain methylnicotinamide, then condensed with monochloroacetone to obtain N-methyl-N-(2-oxopropyl) nicotinamide, then self-aldol condensed to obtain 1-methyl...