ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,454,712, issued on Oct. 28, was assigned to ShenZhen Rhegen Biotechnology Co. Ltd. (Shenzhen, China).
"Method for large-scale synthesis of long-chain RNA and method for site-specific modification of long-chain RNA" was invented by Yong Hu (Shenzhen, China) and Miaomiao Zhang (Shenzhen, China).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are a method for large-scale synthesis of a long-chain RNA and a method for site-specific modification of the long-chain RNA. The method for large-scale synthesis of a long-chain RNA comprises: designing short RNA fragments and splint DNA fragments; ligating; capping; and removing the splint DNA fragments and o...