US Patent Issued to SHANGHAI YUANSONG BIOTECHNOLOGY on March 25 for "Oncolytic virus expressing PD-1 binding protein and application of oncolytic virus" (Chinese Inventors)

ALEXANDRIA, Va., March 26 -- United States Patent no. 12,258,408, issued on March 25, was assigned to SHANGHAI YUANSONG BIOTECHNOLOGY Co. LTD. (Shanghai).

"Oncolytic virus expressing PD-1 binding protein and application of oncolytic virus" was invented by Kangjian Zhang (Shanghai), Xianlong Fang (Shanghai), Jinfa Gu (Shanghai) and Xinyuan Liu (Shanghai).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided is an oncolytic virus expressing a PD-1 binding protein, i.e., an oncolytic adenovirus comprising a fusion protein expressing a PD-1 single-chain antibody, wherein the fusion protein has a structure of S-VL-L-VH-Fc, S is an optional signal peptide sequence, VL is the light chain variable region of the PD-...