US Patent Issued to SHANGHAI OCEAN UNIVERSITY on April 22 for "Use of ZC3H12B gene or protein and method for establishing animal model of liver disease" (Chinese Inventors)

ALEXANDRIA, Va., June 6 -- United States Patent no. 12,282,023, issued on April 22, was assigned to SHANGHAI OCEAN UNIVERSITY (Shanghai).

"Use of ZC3H12B gene or protein and method for establishing animal model of liver disease" was invented by Guijun Guan (Shanghai) and Yuyang Chang (Shanghai).

According to the abstract* released by the U.S. Patent & Trademark Office: "The gene editing technology was used to carry out target knockout of zc3h12b gene of Oryzias latipes, establishing Oryzias latipes missing Zc3h12b protein product. The established Oryzias latipes all show different degrees of liver lesions such as hepatobiliary duct hyperplasia and fusion, hepatocyte steatosis, and fibrosis. With increase of months, significant fatty liver...