ALEXANDRIA, Va., Feb. 3 -- United States Patent no. 12,540,138, issued on Feb. 3, was assigned to SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY Co. LTD. (Shanghai) and YANGTZE RIVER PHARMACEUTICAL GROUP Co. LTD. (Jiangsu, China).
"Substituted oxaspiro[4.5decanes as MOR receptor agonists" was invented by Bin Hu (Shanghai), Kai Zhang (Shanghai) and Huiping Guan (Shanghai).
According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are an optically pure oxaspiro-substituted pyrrolopyrazole derivative, a preparation method therefor and the pharmaceutical use thereof. The compounds are compounds as shown in formula (I) and formula (II) or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a prodrug ther...