US Patent Issued to SHANDONG UNIVERSITY on Sept. 30 for "L-2-hydroxyglutarate biosensor based on specific transcriptional regulator and application thereof" (Chinese Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,429,423, issued on Sept. 30, was assigned to SHANDONG UNIVERSITY (Qingdao, China).

"L-2-hydroxyglutarate biosensor based on specific transcriptional regulator and application thereof" was invented by Chao Gao (Qingdao, China), Zhaoqi Kang (Qingdao, China), Cuiqing Ma (Qingdao, China) and Ping Xu (Qingdao, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "A transcriptional regulator LhgR is specifically responsive to L-2-hydroxyglutarate (L-2-HG) and an L-2-HG biosensor based on this transcriptional regulator; wherein the biosensor is a fusion protein of cyan fluorescent protein mTFP, L-2-HG specific transcriptional regulator LhgR, and yellow fluores...