ALEXANDRIA, Va., July 16 -- United States Patent no. 12,357,698, issued on July 15, was assigned to SHANDONG NORMAL UNIVERSITY (Jinan, China).

"FUS proteolysis-targeting chimera, preparation method and applications thereof" was invented by Jun Zhou (Jinan, China) and Songbo Xie (Jinan, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention belongs to the technical field of proteolysis-targeting chimera preparation and biomedical technology, and specifically relates to a FUS proteolysis-targeting chimera, preparation method and applications thereof. Specifically, the present invention designed ligands specifically binding to FUS based on the "GGUG" RNA motif that specifically binds to FUS,...