US Patent Issued to SEIKAGAKU on Feb. 3 for "Horseshoe crab factor B variant" (Japanese Inventors)

ALEXANDRIA, Va., Feb. 3 -- United States Patent no. 12,540,349, issued on Feb. 3, was assigned to SEIKAGAKU Corp. (Tokyo).

"Horseshoe crab factor B variant" was invented by Yuki Kobayashi (Tokyo), Hikaru Mizumura (Tokyo), Toshio Oda (Tokyo) and Shun-ichiro Kawabata (Fukuoka, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided is a technology related to a horseshoe crab factor B variant, and also provided is means for performing endotoxin measurement with high sensitivity. A polypeptide having an amino acid sequence in which the amino acid residue at the 193-position in an amino acid sequence of a polypeptide of horseshoe crab factor B is substituted with a cysteine (Cys) residue, is produced. Endot...