US Patent Issued to SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATION on May 27 for "Selective BTK irreversible inhibitors" (California Inventors)

ALEXANDRIA, Va., June 17 -- United States Patent no. 12,312,354, issued on May 27, was assigned to SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATION (San Diego).

"Selective BTK irreversible inhibitors" was invented by Jeffrey L. Gustafson (San Diego), Sean Thomas Toenjes (San Diego), Samuel T. Albright (San Diego) and Ramsey Hazin (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides a series of conformationally stable and selective, irreversible kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds. The compounds herein are atropiso...