ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,448,636, issued on Oct. 21, was assigned to Salk Institute for Biological Studies (La Jolla, Calif.).
"High-efficiency reconstitution of RNA molecules" was invented by Lukas Christoph Bachmann (San Diego) and Samuel Lawrence Pfaff (San Diego).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are synthetic RNA molecules for reconstitution of RNA molecules, including compositions and methods of using these molecules. For example, such molecules can be used to deliver a protein coding sequence over two or more viral vectors (such as AAVs), resulting in reconstitution of the full-length protein in a cell. Such methods can be used to deliver a th...