US Patent Issued to Salk Institute for Biological Studies on April 22 for "Exogenous gene expression in recombinant adenovirus for minimal impact on viral kinetics" (California Inventors)

ALEXANDRIA, Va., June 6 -- United States Patent no. 12,281,324, issued on April 22, was assigned to Salk Institute for Biological Studies (La Jolla, Calif.).

"Exogenous gene expression in recombinant adenovirus for minimal impact on viral kinetics" was invented by Clodagh O'Shea (San Diego), William Partlo (San Diego) and Colin Powers (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "Recombinant adenovirus genomes that include an exogenous open reading frame (ORF) and a self-cleaving peptide coding sequence are described. Optimal placement of the exogenous genes for minimal impact on viral kinetics is further disclosed. Therapeutic applications of the recombinant adenoviruses are also described."

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