ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,435,355, issued on Oct. 7, was assigned to Roche Sequencing Solutions Inc. (Pleasanton, Calif.).
"Whole transcriptome analysis in single cells" was invented by Sedide Ozturk (Pleasanton, Calif.), Martin Ranik (Santa Clara, Calif.) and Florian Rubelt (Menlo Park, Calif.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention is a method of single cell transcriptome analysis. The method comprises detecting multiple transcripts in each individual cell of the plurality of cells by barcoding the transcripts with a cell-specific compound barcode formed using a DNA polymerase and a terminal transferase, optionally in a single enzyme such as a reverse trans...