US Patent Issued to Roche Sequencing Solutions on July 15 for "Alpha-hemolysin variants and uses thereof" (California Inventor)

ALEXANDRIA, Va., July 16 -- United States Patent no. 12,358,956, issued on July 15, was assigned to Roche Sequencing Solutions Inc. (Pleasanton, Calif.).

"Alpha-hemolysin variants and uses thereof" was invented by Timothy K. Craig (Campbell, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein are variants of alpha-hemolysin having at least one mutation, such as a mutation to a positive charge. In certain examples, the mutation is selected from 0K, A1K, A1R, D2N, S3K, D4K, D4N, K8R, N47K, E70K, S106K, E111N, 127-131G, D128K, K147N, V149K, E287R, M298A, or combinations thereof in the mature, wild-type alpha-hemolysin amino acid sequence. Also provided are compositions including the variants ...