ALEXANDRIA, Va., Sept. 23 -- United States Patent no. 12,421,268, issued on Sept. 23, was assigned to Roche Innovation Center Copenhagen A/S (Horsholm, Denmark).

"Process for preparing nucleotide P(V) monomers" was invented by Dace Katkevica (Riga, Latvia), Martins Katkevics (Riga, Latvia), Erik Funder (Hillerod, Denmark) and Nanna Albaek (Birkerod, Denmark).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to an optimized method for preparing a P(V) monomer of formula (IIIa) or (IIIb) from a nucleoside using DBU as a base at about 0.8 equivalent to nucleoside."

The patent was filed on April 14, 2020, under Application No. 17/604,550.

*For further information, including images, ch...