US Patent Issued to RIVER STONE BIOTECH on Dec. 23 for "Microbial cell with improved in vivo conversion of thebaine/oripavine" (Danish Inventors)

ALEXANDRIA, Va., Dec. 23 -- United States Patent no. 12,503,706, issued on Dec. 23, was assigned to RIVER STONE BIOTECH LLC (Cambridge, Mass.).

"Microbial cell with improved in vivo conversion of thebaine/oripavine" was invented by Esben Halkjaer Hansen (Copenhagen, Denmark), Swee Chuang Lim Hallwyl (Copenhagen, Denmark), Hussam Hassan Nour-Eldin (Copenhagen, Denmark) and Zeinu Mussa Belew (Copenhagen, Denmark).

According to the abstract* released by the U.S. Patent & Trademark Office: "A recombinant microbial host cell having improved in vivo conversion of reticuline and derivatives thereof (such as thebaine and/or oripavine) to relevant downstream opioids (such as neopinone, oripavine, northebaine, nororipavine or morphinone) and relate...