ALEXANDRIA, Va., Nov. 11 -- United States Patent no. 12,467,073, issued on Nov. 11, was assigned to RICHTER-HELM BIOLOGICS GMBH & Co. KG (Hamburg, Germany).
"Methods for producing plasmid DNA" was invented by Michael Kuchler (Hamburg, Germany), Christian Kaiser (Hamburg, Germany) and Bjorn Kruger (Hamburg, Germany).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to a method of isolating covalently closed circular (ccc) DNA molecules from microbial cells containing the ccc DNA molecules, comprising the steps of: contacting the microbial cells with a lysing agent and moving the composition through a tube system with a flow having a Reynolds number of at least 3000 to obtain a lysing...