ALEXANDRIA, Va., March 19 -- United States Patent no. 12,251,389, issued on March 18, was assigned to REMEDY PHARMACEUTICALS INC. (New York).

"Methods of treating ischemic stroke at risk for cerebral or cerebellar edema" was invented by Sven Martin Jacobson (New York) and Thomas W. Macallister (Montross, Va.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to the treatment of ischemic stroke at risk of brain swelling using SUR1-TRPM4 channel inhibitors in combination with mechanical thrombectomy. In some embodiments, the methods include treating patients suffering from a large hemispheric infarction. In certain embodiments, patients have a lesion volume of less than 140 cm3 or less than 1...