ALEXANDRIA, Va., Sept. 23 -- United States Patent no. 12,419,963, issued on Sept. 23, was assigned to REGENERON PHARMACEUTICALS INC. (Tarrytown, N.Y.).
"Diels-Alder conjugation methods" was invented by Thomas Nittoli (Orangeburg, N.Y.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein are protein-payload conjugates and compositions thereof that are useful, for example, for target-specific delivery of therapeutic and/or imaging agent moieties. In certain embodiments, provided are specific and efficient methods for producing protein-payload constructs (e.g., antibody-drug conjugates) utilizing a combination of transglutaminase and Diels-Alder techniques. Antibody-drug conjugates and compositions w...