US Patent Issued to Regeneron Pharmaceuticals on Sept. 16 for "Genetically modified major histocompatibility complex mice" (New York, Maryland Inventors)

ALEXANDRIA, Va., Sept. 17 -- United States Patent no. 12,414,551, issued on Sept. 16, was assigned to Regeneron Pharmaceuticals Inc. (Tarrytown, N.Y.).

"Genetically modified major histocompatibility complex mice" was invented by Lynn Macdonald (Harrison, N.Y.), Andrew J. Murphy (Croton-on-Hudson, N.Y.), Vera Voronina (North Bethesda, Md.) and Cagan Gurer (Chappaqua, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I and MHC II polypeptides and/or human or humanized Beta2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said ge...