US Patent Issued to Regeneron Pharmaceuticals on Oct. 7 for "Humanized light chain mice" (New York, California Inventors)

ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,433,266, issued on Oct. 7, was assigned to Regeneron Pharmaceuticals Inc. (Tarrytown, N.Y.).

"Humanized light chain mice" was invented by Lynn Macdonald (Harrison, N.Y.), Cagan Gurer (Chappaqua, N.Y.), Karolina A. Hosiawa (Yorktown Heights, N.Y.), Sean Stevens (Del Mar, Calif.) and Andrew J. Murphy (Croton-on-Hudson, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a mouse, wherein the non-human animals express a human immunoglobulin heavy chai...