ALEXANDRIA, Va., Nov. 18 -- United States Patent no. 12,473,574, issued on Nov. 18, was assigned to REGENERON PHARMACEUTICALS INC. (Tarrytown, N.Y.).
"Methods for modifying a genome" was invented by Aris N. Economides (Tarrytown, N.Y.), Andrew J. Murphy (Croton-on-Hudson, N.Y.), Peter Matthew Lengyel (Brooklyn, N.Y.) and Peter H. A. Yang (Tarrytown, N.Y.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Methods for modifying a genome are provided, wherein the modifications comprise null alleles, conditional alleles and null alleles comprising conditional by inversion elements. Methods are provided which afford the ability in a single targeting step to introduce an allele that can be used to generate a null alle...