US Patent Issued to Regeneron Pharmaceuticals on March 4 for "Humanized IL-6 and IL-6 receptor" (New York, California Inventors)

ALEXANDRIA, Va., March 5 -- United States Patent no. 12,239,111, issued on March 4, was assigned to Regeneron Pharmaceuticals Inc. (Tarrytown, N.Y.).

"Humanized IL-6 and IL-6 receptor" was invented by Li-Hsien Wang (Somers, N.Y.), Anthony T. Dore Jr. (Tarrytown, N.Y.), Sean Stevens (Del Mar, Calif.) and Andrew J. Murphy (Croton-on-Hudson, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6RAlpha locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL...