ALEXANDRIA, Va., Feb. 26 -- United States Patent no. 12,234,277, issued on Feb. 25, was assigned to Regeneron Pharmaceuticals Inc. (Tarrytown, N.Y.).
"Hydrophobic interaction chromatography for viral clearance" was invented by John Ruppino (Boonton, N.J.), John Mattila (Nyack, N.Y.) and Robert Stairs (Wellborn, Fla.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present application provides a method for characterizing and/or determining viral clearance capacity of hydrophobic interaction chromatography (HIC) including experimental design for multivariate analysis of viral clearance of HIC. The method provides understanding of the mechanism of the viral clearance using HIC by running a D-Optimal design of...