US Patent Issued to Regeneron Pharmaceuticals on Feb. 10 for "Non-human animals expressing pH-sensitive immunoglobulin sequences" (North Carolina, New York Inventors)

ALEXANDRIA, Va., Feb. 11 -- United States Patent no. 12,543,711, issued on Feb. 10, was assigned to Regeneron Pharmaceuticals Inc (Tarrytown, N.Y.).

"Non-human animals expressing pH-sensitive immunoglobulin sequences" was invented by John McWhirter (Greenville, N.C.), Lynn Macdonald (Harrison, N.Y.), Joel H. Martin (Putnam Valley, N.Y.) and Andrew J. Murphy (Croton-on-Hudson, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Genetically modified non-human animals are provided that express an immunoglobulin variable domain that comprises at least one histidine, wherein the at least one histidine is encoded by a substitution of a non-histidine codon in the germline of the animal with a histidine codon, or th...