ALEXANDRIA, Va., Aug. 20 -- United States Patent no. 12,391,734, issued on Aug. 19, was assigned to REGENERON PHARMACEUTICALS INC. (Tarrytown, N.Y.).

"PD-1 homing endonuclease variants, compositions, and methods of use" was invented by Jasdeep Mann (Seattle), Joel Gay (Seattle), Jordan Jarjour (Seattle) and Joy Zhang (Seattle).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides improved genome editing compositions and methods for editing a PD-1 gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of, a cancer, an infectious disease, an autoimmune disease, an inflammatory disease, or an immunodeficiency."

Th...