US Patent Issued to Regeneron Pharmaceuticals on Aug. 19 for "Mice expressing a limited immunoglobulin light chain repertoire" (American, Italian Inventors)

ALEXANDRIA, Va., Aug. 20 -- United States Patent no. 12,389,888, issued on Aug. 19, was assigned to Regeneron Pharmaceuticals Inc. (Tarrytown, N.Y.).

"Mice expressing a limited immunoglobulin light chain repertoire" was invented by John McWhirter (Sanremo, Italy), Lynn Macdonald (Harrison, N.Y.), Sean Stevens (Del Mar, Calif.) and Andrew J. Murphy (Croton-on-Hudson, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that present a choice of two human light chain variable gene segments such that the immunoglobulin l...