US Patent Issued to REATA PHARMACEUTICALS HOLDINGS on Aug. 12 for "2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof" (Illinois Inventors)

ALEXANDRIA, Va., Aug. 12 -- United States Patent no. 12,384,815, issued on Aug. 12, was assigned to REATA PHARMACEUTICALS HOLDINGS LLC (Plano, Texas).

"2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof" was invented by Ahmad Y. Sheikh (Deerfield, Ill.), Alessandra Mattei (Chicago) and Xiu C. Wang (Green Oaks, Ill.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide,polymorphic forms thereof, methods for preparation and us...