ALEXANDRIA, Va., Sept. 23 -- United States Patent no. 12,421,191, issued on Sept. 23, was assigned to RaQualia Pharma Inc. (Aichi, Japan).
"3-hydroxyoxindole derivatives as CRHR2 antagonist" was invented by Kazuo Ando (Aichi, Japan), Masashi Ohmi (Aichi, Japan) and Ryohei Magara (Aichi, Japan).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to 3-hydroxyoxindole derivatives which have antagonistic activities against CRHR2, and which are useful in the treatment or prevention of disorders and diseases in which CRHR2 is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or tre...