US Patent Issued to Rapa Therapeutics on March 4 for "ALS treatment using induced regulatory T (iTREG) cells" (Maryland Inventor)

ALEXANDRIA, Va., March 5 -- United States Patent no. 12,239,647, issued on March 4, was assigned to Rapa Therapeutics LLC (Rockville, Md.).

"ALS treatment using induced regulatory T (iTREG) cells" was invented by Daniel Harding Fowler (Bethesda, Md.).

According to the abstract* released by the U.S. Patent & Trademark Office: "T cells harvested from an ALS patient are subjected to a de-differentiation and re-differentiation process to yield TREG/Th2 hybrid T cells and are then administered to the ALS patient as a cell therapy. The harvested T cells are first cultured in medium containing vitamin D, temsirolimus, and an IL-2 signaling inhibitor to de-differentiate the cells and then the de-differentiated cells are then transferred to a cult...